How can cannabis oral bioavailability be increased?
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How can cannabis oral bioavailability be increased?
It is possible to increase the oral bioavailability of cannabinoids by using drug delivery systems that promote solubilization. Lipid delivery systems and oil-in-water (O/W) emulsion delivery systems are known to increase the bioavailability of lipophilic drugs through solubilization [10-12]. A pharmacokinetic study titled: Pharmacokinetics of CBD Taken Orally (PK Oral CBD) was conducted to evaluate the impact of these delivery systems on the bioavailability of a model cannabinoid: CBD. In the PK Oral CBD study, three formulas were compared: CBD with no delivery system, CBD in a lipid delivery system and CBD in Realize TM emulsion delivery system. The results of the PK Oral CBD study are presented in Figure 2.
Author: Michael Heller PhD
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